Life begins and ends in the cell. When our cells are impacted by mycotoxins, and other toxicants, the entire body is affected, including our mast cells. One such toxin that can destabilize the entire body is something called a Trichothecene mycotoxin.
What on earth is that? Trichothecene mycotoxins are a class of potent toxins produced by various species of mold (fungi). You may have heard about them through the mention of black mold, aka Stachybotrous since trichothecene mycotoxins are one of the poisons that Stachybotrous produces. These destructive toxins are known to cause a wide range of health effects in humans and animals. One of the key mechanisms by which trichothecene mycotoxins exert their toxic effects is through their ability to disrupt the function of mast cells. Buckle up as we dive into the impact of Trichothecene Mycotoxins on mast cells and how we can support the body.

What are mast cells, and why are they important?

In addition to activating and degranulating mast cells, trichothecene mycotoxins can also inhibit the synthesis of prostaglandins and leukotrienes. Prostaglandins and leukotrienes are important mediators of inflammation, and their synthesis is regulated by the enzyme cyclooxygenase. Trichothecene mycotoxins inhibit the activity of cyclooxygenase, leading to a reduction in the synthesis of prostaglandins and leukotrienes. In layman’s terms, trichothecene mycotoxins can cause immune suppression, which means that the body has a reduced ability to fight infections and other diseases (sigh).

DNA & Mitochndria 
These mycotoxins can also have direct toxic effects on mast cells by damaging the DNA and mitochondria of mast cells. In vitro studies have shown that exposure to these toxins can lead to the death of mast cells, likely through the generation of reactive oxygen species. This can further contribute to their immune-suppressive effects and increase the risk of infection and other health problems.

In adults and children, symptoms from exposure to Trichothecene mycotoxins and their effect on mast cells can cause Mast Cell Activation Syndrome. Symptoms may present as follows:

-sudden anaphylactic reactions 
-headaches and difficulting thinking
-dizziness, nausea, and vomiting
-flushing on the face, neck, and or chest (redness)
-itchy skin
-sudden and reoccurring hives (they may appear one day, disappear the next and return again)
-stomach pain 
-sudden or severe intolerance to foods
-sudden or severe intolerance to supplements
-sudden or severe intolerance to changes in temperature 
-difficulty breathing
-increased mucous production
-interstitial cystitis, bladder pain/pressure
-frequent urination
-sensitivity to fragrances and odors 
-new or sudden anaphylactic reactions
-easy bruising 
-excessive mucous production when eating high histamine foods (this usually comes on suddenly)

Important Steps for Healing
-Avoiding triggers and looking into the living and working environment should be step #1. Doing this is absolutely imperative. In many cases, toxic mold exposure is what destabilizes the mast cells, to begin with, and the body becomes more reactive to things in the environment, infections, and even food. Mast Cell Activation Syndrome and histamine intolerance are, in many cases, caused, in my experience, by toxic mold exposure. Avoiding triggers in the diet is also important but will look different for everyone. To rule out potential food triggers try an elimination diet. Starting costs nothing but can provide a wealth of information on what should and shouldn’t be avoided.

-Watch out for radioactive elements in water, as exposure can cause or worsen flares, especially in children. To read more about this, click here.  

-Work on regulating the nervous system and supporting the vagus nerve can be a great help, especially if supplements aren’t tolerated. 

-Add manual lymphatic drainage starting once a week and then increase slowly to once a day. 

-Support the thymus and spleen gently and, if well tolerated (see supplements below).

-Support the body by maintaining mineral balance. Magnesium is very important, especially since deficiency has been found to increase the release of histamine from mast cells, which can lead to increased inflammation and other immune responses. 

-Try to follow a low histamine diet and take DAO enzymes and/or a digestive support blend prior to eating. The support blend I like the most is Tributyrin-X™ which is listed below. 

-Try Infrared sauna therapy if tolerated. I do not recommend dry, steam, or heated rock saunas as they can make MCAS symptoms worse. Infrared saunas use infrared light to heat the body rather than heating the air around the body, as traditional saunas do. In my experience, starting with 5 minutes once or twice a week has been helpful and well-tolerated. Prior to doing infrared sauna therapy, I always recommend supplementing with whatever you find helpful for your MCAS; see the supplement suggestion below. If tolerated, I also recommend opening up a half dose of a well-tolerated binder like the one mentioned in the supporting supplements section below. 

Supporting Supplements

NeuroProtek – Histamine-regulating flavonoids that help maintain healthy histamine levels, promote healthy inflammation levels, and help stabilize mast cells. 

Tributyrin-X –  Taken with food to help support healthy mast cells and histamine levels. Helps soothes histamine reactions. 

Hista-Aid – Can help inhibit excess histamine release, support the body’s own antioxidant switch, and assist the body’s ability to break down histamine.

HistamineX – Contains complementary plant compounds that support healthy mast cell function and normal histamine storage and release.

Mirica Advanced – Potent anti-inflammatory that helps regulate mast cell activation and degranulation.

Organic Camu Camu – Natural, source of vitamin C, natural antihistamine.

CBD Gummies 25mg – CBD can suppress the signaling of mast cells and reduce inflammation.

Zinc Carnosine – A unique combination of zinc and L-carnosine, which synergistically supports your stomach and intestinal mucosal lining, gut wall integrity, and healthy inflammatory processes to support healthy gastrointestinal function.

Magnesium Breakthrough – Full spectrum of all seven forms of the most bioavailable magnesium.

Grass Fed Beef Thymus Supplement – Source of vitamin A, B12, copper, folate, choline, iron & hyaluronic acid. 

Grass Fed Beef Spleen Supplement – Rare animal source of vitamin C, proteins, and also usually contains iron, selenium, vitamin B12, as well as other nutrients such as phosphorus, vitamin B3, and and minerals. Beef spleen meat usually features highly bioavailable heme iron, and also tuftsin and splenopentin.

Pure Electolyte Concentrate – Mimics electrolyte levels in the body for optimal hydration. Formulated with the three ingredients you need to bring electrolytes back to the perfect pH balance – Sodium, Potassium, and Magnesium.

Takesumi Supreme Gentle Binder – Derived from bamboo that is carbonized under very specific conditions. It helps with those suffering from issues that would benefit from detoxification and food reactivity. Its properties help ease the load on the liver and kidneys.

Stinging Nettles – Acts an a gentle antihistamine. Nettles block histamine production naturally. 

I hope you found this post about the impact of Trichothecene Mycotoxins on mast cells and that you found helpful tips on how to support the body, helpful. If you did, please share it with others. 

Chemical Free Gal – If you enjoyed this post and would like to support me so that I can continue to provide valuable resources and help to people in our community, click here.

Disclaimer: The information provided on is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. The content on this site is not intended to diagnose, treat, cure or prevent any disease. Any views or opinions written in this blog should not be taken as fact or professional advice. This post has affiliate links. This means that, at zero cost to you, I may earn an affiliate commission if you click through the link and finalize a purchase.

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